GPR10 as a target for identifying weight modulating compounds
US6537765B2 · kind B2 · utility
16Cited by
0References
16Claims
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Assignee
Inventors
Key dates
| Filing date | Mar 6, 2001 |
| Grant date | Mar 25, 2003 |
| Priority date | — |
| Expiry date | Mar 6, 2021 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA01K2217/05
- WIPO fieldMeasurement
- WIPO sectorInstruments
Abstract
Assays for the identification of compounds useful for the modulation of body weight, metabolic rate, or feeding behavior are disclosed. Such compounds are useful for the treatment body weight disorders, e.g., obesity and cachexia. The methods involve cell-free and cell-based assays that identify compounds which alter ligand binding to and/or alter the activity of GPR10, a G protein-coupled receptor, optionally followed by an in vivo assay of the effect of the compound on feeding behavior, body weight, or metabolic rate.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.