Nucleotide sequence of the mycoplasma genitalium genome, fragments thereof, and uses thereof

US6537773B1 · kind B1 · utility

Assignees

• The Institute for Genomic Research · US
• THE JOHNS HOPKINS UNIVERSITY · US
• The University of North Carolina at Chapel Hill · US

Inventors

• Claire Fraser · Centreville, US
• Mark D. Adams · Potomac, US
• Jeannine D. Gocayne · Potomac, US
• Clyde A. Hutchison · Village of La Jolla, US
• Hamilton O. Smith · San Diego, US
• J. Craig Venter · Village of La Jolla, US
• Owen White · Gaithersburg, US

Key dates

• Filing date: Oct 19, 1995
• Grant date: Mar 25, 2003
• Expiry date: Dec 4, 2015

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61K38/00
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The present invention provides the nucleotide sequence of the entire genome of Mycoplasma genitalium, SEQ ID NO:1. The present invention further provides the sequence information stored on computer readable media, and computer-based systems and methods which facilitate its use. In addition to the entire genomic sequence, the present invention identifies protein encoding fragments of the genome, and identifies, by position relative to two (2) genes known to flank the origin of replication, any regulatory elements which modulate the expression of the protein encoding fragments of the Mycoplasma genitalium genome.