Patent · US Expired

Compositions and methods for use in targeting vascular destruction

US6538038B1 · kind B1 · utility

35Cited by
1References
12Claims
0Family size

Assignee

Inventors

Key dates

Filing dateFeb 16, 2000
Grant dateMar 25, 2003
Priority date—
Expiry dateFeb 16, 2020

Classification

  • Technology area (CPC A)Human Necessities
  • CPC primaryA61P43/00
  • WIPO fieldPharmaceuticals
  • WIPO sectorChemistry

Abstract

Treatment of warm-blooded animals having a tumor or non-malignant hypervascularation, by administering a sufficient amount of a cytotoxic agent formulated into a phosphate prodrug form having substrate specificity for microvessel phosphatases, so that microvessels are destroyed preferentially over other normal tissues, because the less cytotoxic prodrug form is converted to the highly cytotoxic dephosphorylated form.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.