Crystallizable farnesyl protein transferase compositions, crystals thereby obtained, and methods for use
US6539309B1 · kind B1 · utility
5Cited by
2References
4Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Jul 29, 1999 |
| Grant date | Mar 25, 2003 |
| Priority date | — |
| Expiry date | Jul 29, 2019 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07K2299/00
- WIPO fieldBiotechnology
- WIPO sectorChemistry
Abstract
The present invention relates to compositions and crystals of farnesyl protein transferase and farnesyl protein transferase in complex with substrates and inhibitors. Also disclosed are crystallization conditions for these compositions and their use for structural determination of FPT:FPP/FPP analog:peptide/inhibitor complexes.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.