Method and device for in-situ formulation of a medicinal solution for parenteral application

US6540715B1 · kind B1 · utility

Assignee

• BAYER HEALTHCARE LLC · DE

Inventors

• Bernd Kuhn · Frankfurt am Main, DE
• Georg Wiessmeier · Bensberg, DE
• Roland Rupp · Bensberg, DE
• Bernd Krumbach · Leverkusen, DE
• Lothar Weismantel · Neunburg vorm Wald, DE
• Erhard Herrmann · Leverkusen, DE
• Jurgen Klein · Essen, DE

Key dates

• Filing date: Aug 3, 2000
• Grant date: Apr 1, 2003
• Expiry date: Aug 3, 2020

Classification

• Technology area (CPC B): Performing Operations; Transporting
• CPC primary: B01F35/7174
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Method for the in situ formulation of a medicinal substance solution for parenteral administration, in which at least two metered part-streams are continuously combined with the aid of a mixer to an active ingredient-containing total volumetric flow, characterized in that the resulting medicinal substance solution is not in thermodynamic equilibrium, and in that the resulting total volumetric flow after mixing is 0.2 ml/h to 500 ml/h, preferably 5 ml/h to 500 ml/h, an apparatus for carrying out the method, and an active ingredient administration kit which contains the apparatus.