System for the production of AAV vectors

US6541012B2 · kind B2 · utility

Inventors

• Christoph Bogedain · Munich, DE
• Gerd Maass · Sindelsdorf, DE
• Michael Hallek · Cologne, DE

Key dates

• Filing date: Jul 18, 2001
• Grant date: Apr 1, 2003
• Expiry date: Jul 18, 2021

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C12N2750/14152
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The invention concerns a system comprising an AAV vector, which contains a foreign DNA, and rep 68/78 sequences of AAV with delayed expression, these sequences being present (a) in cis or (b) in trans. The invention also concerns the use of such a system for the production of AAV vectors.