Regeneration and augmentation of bone using mesenchymal stem cells
US6541024B1 · kind B1 · utility
174Cited by
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16Claims
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Key dates
| Filing date | Mar 13, 1998 |
| Grant date | Apr 1, 2003 |
| Priority date | — |
| Expiry date | Mar 13, 2018 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC12N2533/54
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
Disclosed are compositions and methods for augmenting bone formation by administering isolated human mesenchymal stem cells (hMSCs) with a ceramic material or matrix or by administering hMSCs; fresh, whole marrow; or combinations thereof in a resorbable biopolymer which supports their differentiation into the osteogenic lineage. Contemplated is the delivery of (i) isolated, culture-expanded, human mesenchymal stem cells; (ii) freshly aspirated bone marrow; or (iii) their combination in a carrier material or matrix.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.