Methods for solid-phase synthesis of hydroxylamine compounds and derivatives and combinatorial libraries thereof
US6541276B2 · kind B2 · utility
3Cited by
15References
7Claims
0Family size
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Key dates
| Filing date | Oct 27, 1997 |
| Grant date | Apr 1, 2003 |
| Priority date | — |
| Expiry date | Oct 27, 2017 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC40B40/00
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
A novel method for generating hydroxylamine, hydroxamic acid, hydroxyurea, and hydroxylsulfonamide compounds is disclosed. The method involves the nucleophilic attack of an alkoxyamine on a suitable solid phase support. Techniques of combinatorial chemistry can then be applied to the immobilized alkoxyamine to generate a diverse set of compounds. Cleavage of the compounds from the support yields a library of hydroxylamine or hydroxylamine derivative compounds, which can be screened for biological activity (e.g., inhibition of metalloproteases).
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.