Thrombin inhibitors having a lactam at P3
US6541467B1 · kind B1 · utility
8Cited by
1References
24Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Apr 14, 2000 |
| Grant date | Apr 1, 2003 |
| Priority date | — |
| Expiry date | Apr 14, 2020 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61K38/00
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The present invention provides compounds having a lactam ring at P3 and at P1 have a six-membered heterocyclic ring having two ring nitrogen ring atoms and the remainder of the ring atoms carbon atoms. These compounds have biological activity as active and potent inhibitors of thrombin. Their pharmaceutically acceptable salts, pharmaceutical compositions thereof and methods of using these compounds and pharmaceutical compositions comprising these compounds as therapeutic agents for treatment of disease states in mammals which are characterized by abnormal thrombosis are also described.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.