Antithrombotic agents

US6541499B1 · kind B1 · utility

Assignee

• ELI LILLY AND COMPANY · US

Inventors

• Jolie Anne Bastian · Indianapolis, US
• Nickolay Y Chirgadze · Carmel, US
• Michael Lyle Denney · Franklin, US
• Matthew Joseph Fisher · Mooresville, US
• Robert J. Foglesong · Durham, US
• Richard Waltz Harper · Indianapolis, US
• Mary G. Johnson · Carrboro, US
• Valentine Joseph Klimkowski · Carmel, US
• Ho-Shen Lin · Indianapolis, US
• Michael P Lynch · Raleigh, US
• Jefferson Ray McCowan · Indianapolis, US
• Shawn Christopher Miller · Indianapolis, US
• Jeffrey Thomas Mullaney · Indianapolis, US
• Michael Enrico Richett · Indianapolis, US
• Daniel Jon Sall · Greenwood, US
• Gerald Floyd Smith · Indianapolis, US
• Kumiko Takeuchi · Indianapolis, US
• Jennifer Marie Tinsley · Ypsilanti, US
• Michael Robert Wiley · Zionsville, US
• Minsheng Zhang · Hackettstown, US

Key dates

• Filing date: Jan 21, 2000
• Grant date: Apr 1, 2003
• Expiry date: Jan 21, 2020

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D403/12
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The invention relates to novel compounds of formula (I), and their pharmaceutically acceptable salts, as defined herein, processes and intermediates for their preparation, pharmaceutical formulations comprising the novel compounds of formula (I), and the use of the compounds of formula (I) as thrombin inhibitors.