Efficient ligand-mediated Ullmann coupling of anilines and azoles

US6541639B2 · kind B2 · utility

Assignee

• Bristol-Myers Squibb Pharma Company · US

Inventors

• Jiacheng Zhou · Shanghai, CN
• Pasquale N. Confalone · Wilmington, US
• Hui Li · Santa Clara, US
• Philip Ma · Mountain View, US
• Lynette Oh · West Chester, US
• Lucius Rossano · Landenberg, US
• Charles G. Clark · Cherry Hill, US
• Chris Teleha · Bear, US

Key dates

• Filing date: Jul 25, 2001
• Grant date: Apr 1, 2003
• Expiry date: Jul 25, 2021

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D249/08
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

The present invention provides of method of preparing phenyl-substituted azoles. This method uses an efficient ligand-accelerated Ullmann coupling reaction of anilines with azoles. The coupling products are useful for preparing factor Xa inhibitors.