Method of preparing COX-2 inhibitors
US6541646B2 · kind B2 · utility
Assignee
Inventors
Key dates
| Filing date | Apr 8, 2002 |
| Grant date | Apr 1, 2003 |
| Priority date | — |
| Expiry date | Apr 8, 2022 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07C323/19
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
The invention relates to a method for producing compounds of general formula (I) wherein R1 is selected from the following groups: (a) OR5 and (b) mono-, di-, or tri-substituted phenyl; and R2 represents a group (C1-C6) alkyl. The method is characterized in that it comprises the following steps: a) reacting a compound of general formula (III) with an acid of general formula R1CH2 COOH (III) in a water-free medium; b) reacting the resulting compound with a strong base in an aprotic solvent in order to obtain an intermediate cyclic compound which forms a compound of general formula (I) after dehydration; and c) isolating said resulting compound of general formula (I).
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.