Polynucleotides encoding a novel growth factor which acts through ErbB-4 kinase receptor tyrosine
US6544759B1 · kind B1 · utility
7Cited by
1References
8Claims
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Key dates
| Filing date | Apr 21, 2000 |
| Grant date | Apr 8, 2003 |
| Priority date | — |
| Expiry date | Apr 21, 2020 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61P35/00
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
A novel ErbB-4 ligand, referred to herein as Neuregulin-4 (NRG-4) is disclosed as well as polynucleotide sequences encoding NRG-4, oligonucleotides and oligonucleotide analogs derived from polynucleotide sequences, a display library displaying short peptides derived from NRG-4, antibodies recognizing NRG-4, peptides or peptide analogs derived from NRG-4, and pharmaceutical compositions and methods of employing peptides or peptide analogs, oligonucleotides and oligonucleotide analogs, and/or polynucleotide sequences to up-regulate or down-regulate ErbB-4 receptor activity (signaling).
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.