Catechols as antimicrobial agents

US6545015B2 · kind B2 · utility

Assignee

• MERCK & CO., INC. · US

Inventors

• Milton L. Hammond · Somerville, US
• Aaron H. Leeman · Cranford, US
• Milana Maletic · Summit, US
• Gina M. Santorelli · Long Branch, US
• Sherman T. Waddell · Westfield, US
• John Finn · Mercerville, US
• Michael Morytko · Framingham, US
• Jason Hill · Riverview, US
• Dennis Keith · Montclair, US

Key dates

• Filing date: Aug 22, 2001
• Grant date: Apr 8, 2003
• Expiry date: Aug 22, 2021

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D405/12
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

Compounds, pharmaceutically acceptable salts, and compositions thereof of the general formula: wherein Ar is aryl and heteroaryl; R1, R2, R3, and R4 are hydrido, alkyl, cyano, heteroaryl, hydroxy, amino, acylamino, halo, alkoxy, aryloxy, carboxyamido, alkenyl, cycloalkyl, heterocyclyl, acyl, acyloxy, carboalkoxy, carboxy, thio, sulfinyl, sulfonyl and sulfoxy, R5, R6, R7, and R8 are hydrido and lower alkyl; and Het is a nitrogen-containing heterocyclic ring.