Substituted indolinones with kinase inhibitory activity

US6545035B1 · kind B1 · utility

Assignee

• BOEHRINGER INGELHEIM PHARMA GMBH & CO. KG · DE

Inventors

• Armin Heckel · Biberach an der Riß, DE
• Rainer Walter · Biberach, DE
• Wolfgang Grell · Biberach, DE
• Jacobus C. A. van Meel · Mittelbiberach, DE
• Norbert Redemann · Biberach, DE

Key dates

• Filing date: Oct 3, 2001
• Grant date: Apr 8, 2003
• Expiry date: Oct 3, 2021

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D209/34
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

Substituted indolinones of general formula having effect on various kinases and cycline/CDK complexes and on the proliferation of various tumour cells. Exemplary compounds are:3-Z-[1-(4-(N-Benzyl-N-methyl-aminomethyl)-phenylamino)-1-methyl-methylene]-5-amido-2-indolinone and3-Z-[1-(4-(2,3,4,5-Tetrahydro-benzo(d)azepin-3-yl-methyl)-phenylamino)-1-methyl-methylene]-5-amido-2-indolinone.