Methods for purifying telomerase

US6545133B1 · kind B1 · utility

Assignee

• Geron Corporation · US

Inventors

• Scott L. Weinrich · San Francisco, US
• Edward M. Atkinson, III · Seattle, US
• Serge Lichtsteiner · Cupertino, US
• Alain P. Vasserot · South San Francisco, US
• Ronald A. Pruzan · Palo Alto, US

Key dates

• Filing date: Nov 20, 2000
• Grant date: Apr 8, 2003
• Expiry date: Dec 9, 2020

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61K39/00
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

This invention provides purified telomerase and methods of purifying it. The methods involve the use of several sequential steps, including the use of matrices that bind molecules bearing negative charges, matrices that bind molecules bearing positive charges, intermediate-selectivity matrices, methods that separate molecules based on their size, shape, or buoyant density, and by affinity purification.