Patent · US Expired

Method for the production of N-(5-amino-2-cyano-4-fluoro-phenyl)-sulphonamides and new intermediate products

US6545154B2 · kind B2 · utility

0Cited by

7References

7Claims

0Family size

Assignee

BAYER HEALTHCARE LLC · DE

Inventors

Achim Hupperts · Düsseldorf, DE
Mark Wilhelm Drewes · Langenfeld, DE
David Erdman · Neunburg vorm Wald, DE
Reinhard Lantzsch · Leverkusen, DE

Key dates

Filing date	Sep 5, 2001
Grant date	Apr 8, 2003
Priority date	—
Expiry date	Oct 5, 2021

Classification

Technology area (CPC C)Chemistry; Metallurgy
CPC primaryC07C311/48
WIPO fieldOrganic fine chemistry
WIPO sectorChemistry

Abstract

The invention relates to a process for preparing N-(5-amino-2-cyano-4-fluoro-phenyl)-sulphonamides in which, in a first step, 2-amino-4,5-difluoro-benzonitrile is reacted with sulphonyl halides in the presence of an acid acceptor and in the presence of a diluent at temperatures between 0° C. and 150° C. and, in a second step, the N-(2-cyano-4,5-difluoro-phenyl)-sulphonamides and/or N-(2-cyano-4,5-difluoro-phenyl)-sulphonimides obtained in the first step are as pure substances or as mixtures with ammonia in the presence of a diluent reacted at a temperature between 100° C. and 200° C. The invention furthermore relates to novel intermediates of the process.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.