Process to prepare 1-aryl-2-(1-imidazolyl) alkyl ethers and thioethers
US6545163B1 · kind B1 · utility
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15Claims
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Key dates
| Filing date | Oct 2, 1995 |
| Grant date | Apr 8, 2003 |
| Priority date | — |
| Expiry date | Aug 30, 2019 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07D249/08
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
A process is disclosed for the preparation of imidazole derivatives, in particular, 1-aryl-2-(1-imidazolyl) alkyl ethers and thioethers, and more particular for the preparation of tioconazole. The preferred process involves alpha bromination of thiophene in cyclohexane, coupling with an imidazole to form the crude product, and forming the bisulfate salt thereof. The reaction utilizes less hazardous chemicals than currently employed for the production of 1-aryl-2-(1-imidazolyl) alkyl ethers and thioethers, and may be run at room temperature.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.