Method for fixation of biological tissues having mitigated propensity for post-implantation calcification and thrombosis and bioprosthetic devices prepared thereby

US6547827B2 · kind B2 · utility

Assignee

• EDWARDS LIFESCIENCES CORPORATION · US

Inventors

• Alain F. Carpentier · Paris, FR
• Sophie Carpentier · Paris, FR
• Crystal M. Cunanan · Mission Viejo, US
• Lillian Quintero · Chester, US
• Michael N. Helmus · New York, US
• Christine Loshbaugh · Irvine, US
• H. Chris Sarner · Laguna Hills, US

Key dates

• Filing date: Apr 6, 2001
• Grant date: Apr 15, 2003
• Expiry date: Apr 6, 2021

Classification

• Technology area (CPC Y): Emerging Cross-Sectional Technologies
• CPC primary: Y10S623/92
• WIPO field: Medical technology
• WIPO sector: Instruments

Abstract

A method for fixation of biological tissues, and bioprosthetic devices prepared by such method. The method generally comprises the steps of A) fixing the tissue, B) treating the tissue with a mixture of i) a denaturant, ii) a surfactant and iii) a crosslinking agent, C) fabricating or forming the bioprosthesis (e.g., forming the tissue and attaching any non-biological components thereto) and D) subjecting the bioprosthesis to terminal sterilization.