Method for producing solvent-free noncrystalline biologically active substances

US6547997B1 · kind B1 · utility

Assignee

• Abbott Laboratories · US

Inventors

• Jorg Breitenbach · Mannheim, DE
• Ulrich Reinhold · Heidelberg, DE
• Jurgen Zeidler · Mutterstadt, DE
• Jörg Rosenberg · Ellerstadt, DE

Key dates

• Filing date: May 11, 2000
• Grant date: Apr 15, 2003
• Expiry date: May 11, 2020

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61K9/1688
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Solvent-free noncrystalline bioactive substances are prepared from the corresponding crystalline bioactive substances in an extruder by melting the substances in the extruder under reduced pressure and in the absence of auxiliaries, cooling and comminuting.