Dopamine transporter imaging agents

US6548041B1 · kind B1 · utility

Assignees

• Organix, Inc. · US
• President and Fellows of Harvard College · US
• The General Hospital Corporation · US

Inventors

• Peter Meltzer · Lexington, US
• Paul Blundell · Winchester, US
• Bertha K. Madras · Newton, US
• Alan J. Fischman · Boston, US
• Alun G. Jones · Newton, US
• Ashfaq Mahmood · Newton, US

Key dates

• Filing date: May 10, 2000
• Grant date: Apr 15, 2003
• Expiry date: May 10, 2020

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61B6/506
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Radiopharmaceutical compounds are disclosed. A tropane compound is linked through the N atom at the 8-position to a chelating ligand capable of complexing technetium or rhenium to produce a neutral labeled complex that selectively binds to the dopamine transporter over the serotonin transporter with a ratio of 10 or more. These compounds can be prepared as separate diastereoisomers as well as a mixture of diastereoisomers. Also disclosed are radiopharmaceutical kits for preparing the labeled radiopharmaceutical compounds.