Treatment or prophylaxis of diseases caused by pilus-forming bacteria

US6548265B2 · kind B2 · utility

Assignees

• Washington University · US
• SIGA Pharmaceuticals, Inc. · US

Inventors

• Scott Hultgren · Ballwin, US
• Meta Kuehn · Berkeley, US
• Zheng Xu · Vienna, US
• Derek Ogg · Uppsala, SE
• Mark Harris · Uppsala, SE
• Matti Lepisto · Lund, SE
• Charles Hal Jones · Chesterfield, US
• Jan Kihlberg · Mölnlycke, SE

Key dates

• Filing date: Mar 7, 2001
• Grant date: Apr 15, 2003
• Expiry date: Mar 7, 2021

Classification

• Technology area (CPC Y): Emerging Cross-Sectional Technologies
• CPC primary: Y10S435/849
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Novel methods for the treatment and/or prophylaxis of diseases caused by tissue-adhering bacteria are disclosed. By interacting with periplasmic molecular chaperones it is achieved that the assembly of pili is prevented or inhibited and thereby the infectivity of the bacteria is diminished. Also disclosed are methods for screening for drugs as well as methods for the de novo design of such drugs, methods which rely on novel computer drug modelling methods involving an approximative calculation of binding free energy between macromolecules. Finally, novel pyranosides which are believed to be capable of interacting with periplasmic molecular chaperones are also disclosed.