Compounds

US6548504B1 · kind B1 · utility

Assignee

• SmithKline Beeacham P.L.C. · GB

Inventors

• Steven Mark Bromidge · Sawbridgeworth, GB
• Stephen Frederick Moss · Chipping Ongar, GB

Key dates

• Filing date: Jul 19, 2000
• Grant date: Apr 15, 2003
• Expiry date: Jul 19, 2020

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61P25/30
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The present invention therefore provides, in a first aspect, a compound of formula (I) or a salt thereof: in which the group D is selected from a group of formula (A), (B) or (C) below: in whichP is a monocyclic, bicyclic or tricyclic alicyclic ring containing up to 20 carbon atoms in the ring(s);A is a single bond, a C1-6alkylene or a C2-6alkenylene group;R1 is halogen, C1-6alkyl optionally substituted by one or more fluorine atoms, C3-6cycloalkyl, C1-6alkoxy, OCF3, hydroxy, hydroxyC1-6alkyl, hydroxyC1-6alkoxy, C1-6alkoxyC1-6alkoxy, C1-6alkanoyl, amino, alkylamino or dialkylamino, SR11 where R11 is hydrogen or C1-6alkyl or R1 is aryl, arylC1-6alkyl, a bicyclic heterocyclic ring or is a 5 to 7-membered heterocyclic ring each containing 1 to 4 heteroatoms selected from oxygen, nitrogen or sulfur;n is 0, 1, 2 or 3; andR2 is hydrogen, C1-6alkyl, aryl, arylC1-6alkyl or C3-6cycloalkyl; or in which Ra is an alkyl group containing 1 to 20 carbon atoms or is an arylC1-6alkyl group, and Rb is hydrogen or C1-6alkyl;