Sulfonamide derivative as a matrix metalloproteinase inhibitor
US6548667B2 · kind B2 · utility
8Cited by
0References
9Claims
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Assignee
Inventors
Key dates
| Filing date | Dec 6, 2001 |
| Grant date | Apr 15, 2003 |
| Priority date | — |
| Expiry date | Dec 6, 2021 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07D277/74
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The present invention provides a novel sulfonamide derivative of general formula (I) useful as an inhibitor of matrix metalloproteinase (MMP), its isomers, pharmaceutically acceptable salts thereof and a process for preparing the same. Since the sulfonamide derivatives of the present invention selectively inhibit MMP activity in vitro, the MMP inhibitors comprising the sulfonamide derivatives as an effective ingredient can be practically applied for the prevention and treatment of all sorts of diseases caused by overexpression and overactivation of MMP.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.