Racemization of optically active amines

US6548704B2 · kind B2 · utility

Assignee

• BASF SE

Inventors

• Frank Funke · Bischofswerda, DE
• Shelue Liang · Ludwigshafen, DE
• Andreas Kramer · Zürich, CH
• Rainer Stürmer · Bad Dürkheim, DE
• Arthur Hohn · Tauberbischofsheim, DE

Key dates

• Filing date: Dec 12, 2001
• Grant date: Apr 15, 2003
• Expiry date: Dec 12, 2021

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07B2200/07
• WIPO field: Chemical engineering
• WIPO sector: Chemistry

Abstract

Optically active amines of the formula I where R1 and R2 are different and R1, R2, R3 are alkyl, cycloalkyl, arylalkyl, aryl, heteroaryl and heterocyclic radicals and R3 may also be hydrogen (H), with the radicals being able to bear substituents selected from the group consisting of alkyl, cycloalkyl, alkoxy, aryloxy, amino, alkylamino and dialkylamino, are racemized by reacting the optically active amine I in the presence of hydrogen and a hydrogenation or dehydrogenation catalyst at elevated temperature, wherein the catalyst comprises the active components copper and zinc oxide and a support material.