Function-based small molecular weight compound screening system in drosophila melanogaster
US6548733B2 · kind B2 · utility
Assignee
Inventor
Key dates
| Filing date | Dec 21, 1998 |
| Grant date | Apr 15, 2003 |
| Priority date | — |
| Expiry date | Dec 21, 2018 |
Classification
- Technology area (CPC B)Performing Operations; Transporting
- CPC primaryB01J2219/0072
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
A methodology for screening libraries of compounds for desirable biological/therapeutic activities, preferably using an automated system for the microinjection of compound(s) of interest into the open circulatory system (i.e., hemolymph) of Drosophila larvae genetically modified to sensitize a particular signaling pathway related to a human disease either by expression of a human disease gene or by the activation of a Drosophila gene that in the adult fly results in the development of an easily detectable phenotypes such that compounds that selectively interfere with this specific signaling pathway will modify or suppress the phenotype and can be identified rapidly and efficiently.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.