7B2 knockout transgenic animals as models of endocrine disease
US6548736B1 · kind B1 · utility
0Cited by
6References
10Claims
0Family size
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Key dates
| Filing date | Mar 8, 1999 |
| Grant date | Apr 15, 2003 |
| Priority date | — |
| Expiry date | Mar 8, 2019 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA01K2267/0362
- WIPO fieldBiotechnology
- WIPO sectorChemistry
Abstract
In general, the invention features methods and uses for transposon-mediated gene targeting which greatly enhance the insertion and detection of desired genes in genomic exons by homologous recombination. The invention also features transgenic non-human mammals, and eukaryotic cells, wherein a gene encoding 7B2 protein is modified, as well as nucleic acid vectors capable of undergoing homologous recombination with an endogenous 7B2 gene in a cell. The invention also features transgenic non-human mammals as models of endocrine disorders, as well as methods for diagnosing and treating patients with endocrine disorders.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.