Microwave facilitated allyllic substitution

US6551467B1 · kind B1 · utility

Assignee

• Personal Chemistry I Uppsala AB · SE

Inventors

• Ulf Bremberg · Solna, SE
• Anders Hallberg · Stockholm, SE
• Mats Larhed · Munster, DE
• Christina Moberg · Täby, SE
• Nils Kaiser · Uppsala, SE

Key dates

• Filing date: Apr 16, 2001
• Grant date: Apr 22, 2003
• Expiry date: Apr 16, 2021

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07C67/343
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

The present invention is draw to microwave heating of a transition metal-catalysed organic reaction, in which a catalyst complex between a transition metal and an auxiliary ligand or ligands, the ligand being asymmetric or symmetric, monodentate or bidentate, results in highly chemoselective, regioselective, and stereoselective allylic substitution reactions. Molybdenum or palladium complexes form suitable catalytic systems with a plethora of ligands in a variety of solvents for such microwave facilitated nucleophilic substitution reactions.