Bi-and trispecific antibodies for the induction of anti-tumor immunity

US6551592B2 · kind B2 · utility

Assignee

• GSF FORSCHUNGSZENTRUM FUR UMWELT UND GESUNDHEIT GMBH · DE

Inventors

• Horst Lindhofer · Puchheim, DE
• Hans-Jochem Kolb · Hersbruck, DE
• Stefan Thierfelder · Eichenau, DE

Key dates

• Filing date: Sep 3, 1997
• Grant date: Apr 22, 2003
• Expiry date: Sep 3, 2017

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07K2319/00
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

According to the invention, a method is provided wherein intact bispecific or trispecific antibodies which at the same time bind to the T cell receptor complex of a T cell, to tumor-associated antigens on a tumor cell, and, via the Fc portion of the bispecific antibody, to Fc receptor-positive cells are used for the induction of an anti-tumour immunity in humans and animals.