Compositions and methods for delivery of agents for neuronal regeneration and survival
US6551618B2 · kind B2 · utility
Assignees
Inventors
Key dates
| Filing date | Oct 23, 1998 |
| Grant date | Apr 22, 2003 |
| Priority date | — |
| Expiry date | Oct 23, 2018 |
Classification
- Technology area (CPC Y)Emerging Cross-Sectional Technologies
- CPC primaryY10S977/927
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
Devices useful in the delivery of DNA encoding neurotrophic agents, anti-fibrotic agents, and related compositions are disclosed herein for use in the treatment of central and/or peripheral nervous system injury. Methods of making and using the disclosed devices and DNA are also described. In various embodiments, the invention also discloses compositions and devices that may further include a targeting agent, such as a polypeptide that is reactive with an FGF receptor (e.g., bFGF), or another ligand that binds to cell surface receptors on neuronal cells, or a support cell. The invention also discloses methods of promoting neuronal survival and regeneration via transfection of an axon as it grows through a device or composition of the present invention, or via transfection of a repair cell.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.