Screen assay for selecting protein-protein interaction modulators
US6551786B2 · kind B2 · utility
7Cited by
8References
26Claims
0Family size
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Key dates
| Filing date | Jan 4, 2002 |
| Grant date | Apr 22, 2003 |
| Priority date | — |
| Expiry date | Jan 4, 2022 |
Classification
- Technology area (CPC G)Physics
- CPC primaryG01N2500/02
- WIPO fieldMeasurement
- WIPO sectorInstruments
Abstract
A method for selecting compounds capable of modulating protein-protein interactions is provided, in which two fusion proteins are prepared and allowed to interact with each other in the presence of test compounds. The interaction between the two fusion proteins leads to protein trans-splicing, producing an active reporter. Compounds that disrupt or enhance protein-protein interactions can be selected based on the presence or absence of the active reporter.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.