Expression of immunogenic hepatitis B surface antigens in transgenic plants
US6551820B1 · kind B1 · utility
18Cited by
7References
41Claims
0Family size
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Key dates
| Filing date | Dec 23, 1999 |
| Grant date | Apr 22, 2003 |
| Priority date | — |
| Expiry date | Dec 23, 2019 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC12N2730/10122
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
Plant expression vectors comprising at least two expression cassettes are provided which function to reduce transcriptional silencing of polynucleotide expression. Further, novel plant expression vectors for expression of immunogenic polypeptides, including HBsAg, are provided. The plant expression vectors can be used to produce immunogenic polypeptides, including HBsAg, in edible plant tissues. The edible plant tissues can be used to elicit an immune response in humans and animals when the plant tissues are consumed.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.