2-pyrimidineamine derivatives and processes for their preparation
US6552029B1 · kind B1 · utility
Assignee
Inventors
Key dates
| Filing date | Oct 20, 1999 |
| Grant date | Apr 22, 2003 |
| Priority date | — |
| Expiry date | Oct 20, 2019 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07D401/14
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
Compounds of general formula (1) are described wherein:Ar is an optionally substituted aromatic group;R2 is a hydrogen or halogen atom or a group —X1—R2a where X1 is a direct bond or a linker atom or group, and R2a is an optionally substituted straight or branched chain alkyl, alkenyl or alkynyl group;R3 is an optionally substituted heterocycloalkyl group;and the salts, solvates, hydrates and N-oxides thereof.The compounds are selective protein tyrosine kinase inhibitors, particularly the kinases ZAP-70 and syk and are of use in the prophylaxis and treatment of immune or allergic diseases and diseases involving inappropriate platelet activation.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.