Methods and pharmaceutical compositions for inhibiting tumor cell growth
US6552055B2 · kind B2 · utility
15Cited by
1References
4Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Sep 4, 1997 |
| Grant date | Apr 22, 2003 |
| Priority date | — |
| Expiry date | Sep 4, 2017 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61K31/427
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The present invention is based on the finding that activation of PPAR&ggr; plays a key role in inducing growth arrest and differentiation of certain actively proliferating cells. We show that administration of PPAR&ggr; agonists, such as thiazolidinedione ligands (TZDs), is effective both in vitro and in vivo at inhibiting the proiferation of such cells.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.