Method for preparing 2-nitro-5-(phenylthio)-anilines

US6552230B1 · kind B1 · utility

Assignee

• BAYER HEALTHCARE LLC · DE

Inventors

• Volker Glock · Krefeld, DE
• Willi Streicher · Krefeld, DE
• Friedrich-Wilhelm Ullrich · Bensberg, DE

Key dates

• Filing date: Dec 19, 2000
• Grant date: Apr 22, 2003
• Expiry date: Dec 19, 2020

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07C319/14
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

The invention relates to a process for preparing 2-nitro-5-(phenylthio)anilines of formula (I) whereinR1 represents hydrogen, C1-C8-alkyl, C3-C8-cycloalkyl, C1-C8-alkoxy, or halogen andR2 represents hydrogen, C1-C8-alkyl, C3-C8-cycloalkyl, C1-C8-alkoxy, halogen, or C6-C10-aryl optionally substituted with C1-C8-alkyl, C1-C8-alkoxy, or halogen, by reacting, in a solvent, a 5-chloro-2-nitroaniline of the formula (II) wherein R1 is as defined for formula (I),with a thiophenol of the formula (III) wherein R2 is as defined for formula (I), andammonia.