Method of inhibiting the cytocidal effect of TNF with TNF receptor-specific antibodies
US6555111B2 · kind B2 · utility
12Cited by
7References
3Claims
0Family size
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Key dates
| Filing date | Mar 8, 2001 |
| Grant date | Apr 29, 2003 |
| Priority date | — |
| Expiry date | Mar 31, 2021 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07K2319/00
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
Antibodies to Tumor Necrosis Factor receptors (TNF-Rs) which inhibit the cytocidal effect of TNF but not its binding to the TNF-Rs, and ligands interacting with other receptors of the TNF/NGF family, are provided together with methods of producing them. The antibodies preferably bind to the fourth cysteine rich domain of the p75 TNF receptor or to the region between said fourth cysteine rich domain and the cell membrane.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.