Antibodies for inhibiting blood coagulation and methods of use thereof
US6555319B2 · kind B2 · utility
25Cited by
4References
40Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Apr 16, 1999 |
| Grant date | Apr 29, 2003 |
| Priority date | — |
| Expiry date | Apr 16, 2019 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61K38/00
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The invention includes antibodies that provide superior anti-coagulant activity by binding native human TF with high affinity and specificity. Antibodies of the invention can effectively inhibit blood coagulation in vivo. Antibodies of the invention can bind native human TF, either alone or present in a TF:VIIa complex, effectively preventing factor X binding to TF or that complex, and thereby reducing blood coagulation. Preferred antibodies of the invention specifically bind a conformational epitope predominant to native human TF, which epitope provides an unexpectedly strong antibody binding site.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.