Methods for manipulating upper gastrointestinal transit, blood flow, and satiety, and for treating visceral hyperalgesia
US6558708B1 · kind B1 · utility
Assignee
Inventor
Key dates
| Filing date | Apr 10, 2000 |
| Grant date | May 6, 2003 |
| Priority date | — |
| Expiry date | Apr 10, 2020 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61P3/04
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
Disclosed are a method of manipulating the rate of upper gastrointestinal transit of a substance in a mammal. Also disclosed are methods of manipulating satiety and post-prandial visceral blood flow. A method of treating visceral pain or visceral hypersensitivity in a human subject is also described. A method for prolonging the residence time of an orally or enterally administered substance by promoting its dissolution, bioavailability and/or absorption in the small intestine is also described. These methods are related to a method of transmitting to and replicating at a second location in the central nervous system a serotonergic neural signal originating at a first location in the proximal or distal gut of a mammal and/or a method of transmitting to and replicating at a second location in the upper gastrointestinal tract a serotonergic neural signal originating at a first location in the proximal or distal gut.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.