Method for producing structured, self-organized molecular monolayers of individual molecular species, in particular substance libraries

US6558904B2 · kind B2 · utility

Assignee

• CLONDIAG CHIP TECHNOLOGIES GMBH · DE

Inventors

• Eugen Ermantraut · Jena, DE
• Johann Michael Köhler · Golmsdorf, DE
• Torsten Schulz · Pinneberg, DE
• Klaus Wohlfart · Jena, DE
• Stefan Wolfl · Jena, DE

Key dates

• Filing date: Jul 28, 1999
• Grant date: May 6, 2003
• Expiry date: Jul 28, 2019

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C40B60/14
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

The invention relates to a method for producing structured, self-organized molecular monolayers of individual molecular species. The invention is preferably used to create solid-phase bonded substance libraries. To this end, a) a substrate (2) suitable for the first monolayer is provided; b) a microstructured polymer mask (1) having openings is applied to the subtrate (2) at least once in a defined direction. Said polymer mask (1) is sufficiently thin and flexible for it to adhere to the substrate (2) by adhesion, and the material selected for the polymer mask (1) is chemically stable; c) the sandwich constituted by the substrate (2) and polymer mask (1) is flooded with a first agent corresponding to the intended use, so as to create at least one first molecular monolayer in the areas defined by the mask openings; c1) depending on the monolayer structure to be created step c) is repeated using the first agent or one or more additional agents; and d) after carrying out the step described in c) or the steps described in c) and c1), the polymer mask is pulled off after modification of the substrate surface areas which were left uncovered by the mask openings and were subjected to the …