Inhibitors of G protein-mediated signaling, methods of making them, and uses thereof
US6559128B1 · kind B1 · utility
Assignee
Inventors
Key dates
| Filing date | Jan 21, 2000 |
| Grant date | May 6, 2003 |
| Priority date | — |
| Expiry date | Jan 21, 2020 |
Classification
- Technology area (CPC Y)Emerging Cross-Sectional Technologies
- CPC primaryY02A50/30
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The invention provides compositions and methods useful for blocking G protein-mediated signaling events. Compositions provided by the invention relate to carboxy terminal G&agr; peptides, and minigenes which encode such peptides. The invention provides methods of making the minigenes, and methods of using either of the minigenes and the G&agr; carboxy terminal peptides encoded thereby, to block G protein-mediated signaling events. The invention also provides methods of using either of the minigenes and the G&agr; carboxy terminal peptides encoded thereby for the identification of unknown interactions between G proteins and G protein coupled receptors, and for the treatment of pathological disorders associated with G protein-mediated signaling events.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.