Bicyclic amino acids

US6559144B2 · kind B2 · utility

Assignee

• Merck Patentgesellschaft · DE

Inventors

• Beate Diefenbach · Darmstadt, DE
• Simon Goodman
• Joachim Marz · Groß-Gerau, DE
• Peter Raddatz · Darmstadt, DE
• Friedrich Rippmann · Heidelberg, DE
• Matthias Wiesner · Seeheim-Jugenheim, DE

Key dates

• Filing date: Apr 26, 2001
• Grant date: May 6, 2003
• Expiry date: Apr 26, 2021

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D413/12
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

Compounds of the formula I in whichX, Y, Z, R1, R2, R3, R4, R5, R7, R8, R11, m and n have the meanings stated in claim 1, and their physiologically acceptable salts can be used as integrin inhibitors, in particular for the prophylaxis and treatment of circulatory disorders, for thrombosis, myocardial infarct, coronary heart disease, arteriosclerosis, osteoporosis, for pathological processes maintained or propagated by angiogenesis, and in tumour therapy.