Dihydronaphthalene compounds

US6559157B2 · kind B2 · utility

Assignee

• DAIICHI PHARMACEUTICAL CO., LTD. · JP

Inventors

• Rolf Hartmann · Saarburg, DE
• Bertil Wachall · Hemsbach, DE
• Makoto Yoshihama · Utsunomiya, JP
• Masamichi Nakakoshi · Utsunomiya, JP
• Shin Nomoto · Tochigi, JP
• Yoshikazu Ikeda · Kaminokawa, JP

Key dates

• Filing date: May 25, 2001
• Grant date: May 6, 2003
• Expiry date: May 25, 2021

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07C2602/10
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

Dihydronaphthalene compounds have excellent 17&agr;-hydroxylase/C17-20-lyase inhibiting activity, thromboxan A2 synthesis inhibiting activity, and aromatase inhibiting activity and are thereby are useful as preventive and/or therapeutic agents for various male sex hormone- and female sex hormone-dependent diseases such as prostate cancer, prostatomegaly, masculinization, breast cancer, mastopathy, uterine cancer, endometriosis, and ovarian cancer, as well as myocardial infarction, angina pectoris, and bronchial asthma.