Compounds and methods for modulating cxcr3 function
US6559160B1 · kind B1 · utility
Assignee
Inventors
Key dates
| Filing date | Aug 25, 2000 |
| Grant date | May 6, 2003 |
| Priority date | — |
| Expiry date | Aug 25, 2020 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61P43/00
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The invention provides compounds and compositions of the formula: whereinthe subscript n is an integer of from 0 to 4;Ar is a member selected from the group consisting of substituted or unsubstituted aryl and substituted or unsubstituted heteroaryl;R1 is a member selected from the group consisting of substituted or unsubstituted (C5-C15)alkyl;R2 is a member selected from the group consisting of substituted or unsubstituted (C1-C8)alkyl;each R3 is independently a substituent selected from -halogen, —OR′, —OC(O)R′, —NR′R″, —SR′, —R′, —CN, —NO2, —CO2R′, —CONR′R″, —C(O)R′, —OC(O)NR′R″, —NR″C(O)R′, —NR″C(O)2R′, , —NR′—C(O)NR″R′″, —NH—C(NH2)═NH, —NR′C(NH2)═NH, —NH—C(NH2)═NR—, —S(O)R′, —S(O)2R′, —S(O)2NR′R″, —N3, —CH(Ph)2, perfluoro(C1-C4)alkoxy, and perfluoro(C1-C4)alkyl, and where R′, R″ and R′″ are independently selected from hydrogen, (C1-C8)alky…
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.