Antiestrogens, process for their protection and their pharmaceutical use

US6559181B1 · kind B1 · utility

Assignee

• SCHERING CORPORATION · US

Inventors

• Ulrich Klar · Berlin, DE
• Rolf Bohlmann · Berlin, DE
• Karsten Parczyk · Berlin, DE
• Karl-Heinrich Fritzemeier · Berlin, DE
• Monika Lessl · Berlin, DE
• Rosemarie Lichtner · Berlin, DE

Key dates

• Filing date: Nov 7, 2000
• Grant date: May 6, 2003
• Expiry date: Nov 7, 2020

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07C2602/24
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

This invention relates to new antiestrogens of the general formula in which the substituents have the meanings that are explained in more detail in the description.The new compounds are a) pure antiestrogens or b) antiestrogens with partial estrogenic action (tissue-selective estrogens).Based on these properties, the new compounds are suitable for the production of pharmaceutical agents: in the case of a), for example, for the treatment of breast cancer; in the case of b), for example, for hormone replacement therapy.