Method for production of a triazolinethione derivative

US6559317B2 · kind B2 · utility

Assignee

• BAYER HEALTHCARE LLC · DE

Inventors

• Achim Hupperts · Düsseldorf, DE
• Michael Ruther · Monheim, DE
• Manfred Jautelat · Burscheid, DE

Key dates

• Filing date: Jun 14, 2002
• Grant date: May 6, 2003
• Expiry date: Jun 14, 2022

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61P31/00
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

According to a novel process, the triazolinethione derivative of the formula can be prepared bya) reacting the oxirane of the formula  with hydrazine hydrate in the presence of specific diluents, followed by introduction of hydrogen chloride or extraction with aqueous hydrochloric acid,b) treating the resulting hydrazine hydrochloride derivative of the formula  with alkali metal hydroxide in the presence of water and further specific diluents, followed by successive reaction with formaldehyde and thiocyanate of the formulaX—SCN  (IV)  in the presence of certain solvents and finallyc) reacting the triazolidine derivative of the formula  with iron(III) chloride in the presence of aqueous hydrochloric acid.