Converting a pump for use in supercritical fluid chromatography
US6561767B2 · kind B2 · utility
Assignee
Inventors
Key dates
| Filing date | Aug 1, 2001 |
| Grant date | May 13, 2003 |
| Priority date | — |
| Expiry date | Aug 1, 2021 |
Classification
- Technology area (CPC G)Physics
- CPC primaryG01N2030/326
- WIPO fieldMeasurement
- WIPO sectorInstruments
Abstract
A method for converting a pump for use in a flow stream containing a mixture of highly compressed gas, compressible liquid or supercritical fluid wherein the pump delivers a compressible fluid against a back-pressure regulator which in turn delivers a controllable flow rate downstream of the regulator without performing variable compressibility compensation adjustments on the pump. By using a pressurized source of compressible fluid combined with isocratic conditions, the delivery pressure from the pump is controlled at a rate higher than the downstream gradient with the back-pressure regulator, and an inexpensive pump may be used in place of specialized, expensive pumps and compressibility compensation systems for use in stems operating at or near supercritical fluid levels of compressible fluids. Significant capital and operating laboratory costs are saved through a simpler and cheaper system for accurately delivering compressible fluids into mobile phase flow streams.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.