Methods for treating implantable biological tissues to mitigate the calcification thereof and bioprosthetic articles treated by such methods
US6561970B1 · kind B1 · utility
Assignee
Inventors
Key dates
| Filing date | Dec 12, 1996 |
| Grant date | May 13, 2003 |
| Priority date | — |
| Expiry date | Nov 15, 2017 |
Classification
- Technology area (CPC Y)Emerging Cross-Sectional Technologies
- CPC primaryY10S623/915
- WIPO fieldMedical technology
- WIPO sectorInstruments
Abstract
A method for treating fixed biological tissue inhibits calcification of the biological tissue following implantation thereof in a mammalian body. The method includes placing the biological tissue in contact with glutaraldehyde and then heating the glutaraldehyde. Alternatively, methods other than heating (e.g., chemical or mechanical means), for effecting polymerization of the glutaraldehyde may also be utilized. Alternatively, the tissue may be heat treated prior to fixing thereof. Alternatively, methods other than glutaraldehyde may also be used for fixing the tissue. The biological tissue may be so treated at any time prior to implantation thereof in a mammalian body.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.