Arrays with modified oligonucleotide and polynucleotide compositions
US6562569B1 · kind B1 · utility
Assignee
Inventor
Key dates
| Filing date | Mar 13, 2000 |
| Grant date | May 13, 2003 |
| Priority date | — |
| Expiry date | Mar 13, 2020 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07H21/00
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
The present invention provides arrays having associated modified oligonucleotides that selectively bind to DNA or RNA, methods of making such arrays, assays for using such arrays, and the like. In one embodiment, the arrays of the invention exhibit an increased binding affinity with complementary nucleic acids, and in particular with complementary RNA. In another embodiment, the associated nucleic acids of the array of the invention exhibit substantial acid resistance, allowing the arrays to be treated with low pH solutions. In another embodiment, the modified associated nucleic acids of the array of the invention exhibit substantial resistance to nuclease degradation.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.