Oxazolidinone combinatorial libraries, compositions and methods of preparation

US6562844B2 · kind B2 · utility

Assignee

• Pharmacia & Upjohn Company LLC · US

Inventors

• Mikhail Gordeev · Castro Valley, US
• Gary W. Luehr · Foster City, US
• Dinesh V. Patel · Fremont, US
• Zhi-Jie Ni · Emeryville, US
• Eric M. Gordon · Pennington, US

Key dates

• Filing date: Dec 28, 2001
• Grant date: May 13, 2003
• Expiry date: Mar 22, 2022

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C40B40/00
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

Oxazolidinones and methods for their synthesis are provided. Also provided are combinatorial libraries comprising oxazolidinones, and methods to prepare the libraries. Further provided are methods of making biologically active oxazolidinones as well as pharmaceutically acceptable compositions comprising the oxazolidinones. The methods of library preparation include the attachment of oxazolidinones to a solid support. The methods of compound preparation in one embodiment involve the reaction of an iminophosphorane with a carbonyl containing polymeric support.