Process which is useful for converting the carbonyl function in position 4″ of the cladinose unit of an aza-macrolide into an amine derivative
US6562953B2 · kind B2 · utility
2Cited by
1References
26Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | May 16, 2001 |
| Grant date | May 13, 2003 |
| Priority date | — |
| Expiry date | May 16, 2021 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07H17/00
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
The invention relates to a process for preparing compound of general formula I by reductive amination of the corresponding (4″)-carbonyl derivative, characterized in that it comprises:placing the said (4″)-carbonyl derivative in contact with at least one nitrogenous reagent and a Lewis acid under conditions that are favourable for converting the 4″ carbonyl function,reducing the resulting mixture using a reducing agent, andoptionally deprotecting the hydroxyl function in position 2′,to give the expected compound of general formula I.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.